I’m David Slochower, a postdoc with Mike Gilson at UCSD.
I’m working on nonequilibrium statistical mechanics of protein dynamics, computational methods for assessing small molecule binding free energies, and force field development with the Open Force Field Initiative. I also work on simulations of physiological membranes, focusing on the physical chemistry of phosphoinositides.
Ph.D. in Biochemistry and Molecular Biophysics, 2014
University of Pennsylvania
A.B. in Physics with distinction, 2007
See this work highlighted in the Biophysical Journal “New and Notables” Atomic-Scale Insights into Physical Mechanisms Driving Enzymes’ “Working Cycles” by Artem Efremov and Fazoil Ataullakhanov, and the UCSD In the News article It’s not “Intelligent Design” so how did molecular motors develop?.
A new approach to modern collaborative biomolecular force field development based on open source software, open science, and high-quality curated open datasets.
We are developing new methods and tools to calculate the binding free energy of host-guest and protein-ligand systems, with an eye towards drug discovery and supramolecular chemistry.
We are interested in quantifying the performance of molecular motors and how to design motors on the nanoscale for specific properties: speed, torque, gearing, ability to perform work, or other tasks.